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Reference Library

Ethics, Peer-reviewed evidence, Reference Library, Resource Type

Progress in Evidence-Based Medicine: A Historical Perspective

Reference: Djulbegovic, B., & Guyatt, G. H. (2017). Progress in evidence-based medicine: A quarter century on. The Lancet, 390(10091), 415-423. http://doi.org/10.1016/S0140-6736(16)31592-6 Summary: This article traces the evolution of evidence-based medicine (EBM) over 25 years, highlighting its origins in the early 1990s and initial focus on educating clinicians on the use of published research. EBM has […]

COVID-19, Ivermectin, Other viral illnesses, Peer-reviewed evidence, Resource Type, Treatment, Viral illnesses

Ivermectin: A Multifaceted Wonder Drug

Reference: Crump, A. (2017). Ivermectin: enigmatic multifaceted ‘wonder’ drug continues to surprise and exceed expectations. The Journal of Antibiotics, 70(6), 495-505. https://doi.org/10.1038/ja.2017.11 Summary: Over the last decae, ivermectin has gained recognition for its significant contributions to global health. Discovered from a soil microbe in Japan, it was developed by Satoshi Ōmura and William Campbell, who

Antigenic vaccines, General Health, Immunology, Other viral illnesses, Peer-reviewed evidence, Reference Library, Resource Type, Vaccine effectiveness, Vaccines, Viral illnesses

Dendritic Cell Immunotherapy for HIV-1: A Phase IIB Trial

Reference: Jacobson, J. M., Routy, J.-P., Welles, S., DeBenedette, M., Tcherepanova, I., Angel, J. B., Asmuth, D. M., Stein, D. K., Baril, J.-G., McKellar, M., Margolis, D. M., Trottier, B., Wood, K., & Nicolette, C. (2016). Dendritic cell immunotherapy for HIV-1 infection using autologous HIV-1 RNA: A randomized, double-blind, placebo-controlled clinical trial. Journal of Acquired

Antigenic vaccines, General Health, Immunology, Other viral illnesses, Peer-reviewed evidence, Reference Library, Resource Type, Vaccines, Viral illnesses

Immunization of HIV-1-Infected Persons with Dendritic Cells

Reference: Gandhi, R. T., Kwon, D. S., Macklin, E. A., Shopis, J. R., McLean, A. P., McBrine, N., Flynn, T., Peter, L., Sbrolla, A., Kaufmann, D. E., Porichis, F., Walker, B. D., Bhardwaj, N., Barouch, D. H., & Kavanagh, D. G. (2016). Immunization of HIV-1-Infected Persons With Autologous Dendritic Cells Transfected With mRNA Encoding HIV-1

Other viral illnesses, Peer-reviewed evidence, Resource Type, Vaccine effectiveness, Vaccine safety & adverse events, Vaccines, Viral illnesses

Overview of Clinical Development for Vaccines

Reference: Singh, K., & Mehta, S. (2016). The clinical development process for a novel preventive vaccine: An overview. Journal of Postgraduate Medicine, 62(1), 4–11. https://doi.org/10.4103/0022-3859.173187 Summary: The article provides a comprehensive overview of the clinical development process for novel preventive vaccines, detailing the essential phases of vaccine trials: Phase I, II, and III. It highlights

Ethics, Reference Library

Ethics in Health Research: Principles, Processes and Structures

Reference: National Health Research Ethics Council. (2015). Ethics in health research: Principles, processes and structures. Pretoria, South Africa: Department of Health. Summary: The document outlines the ethical guidelines for health research in South Africa, emphasising the need for ethical scrutiny to protect participants’ rights and welfare. It acknowledges South Africa’s unique health context, which necessitates

Other scientific evidence, Other viral illnesses, Resource Type, Treatment, Viral illnesses

Understanding RNA: The Unsung Hero of Genetic Material

Reference: Crossley, M. (2021). Explainer: what is RNA? The Conversation. https://theconversation.com/explainer-what-is-rna-151691 Summary: RNA (ribonucleic acid) is a crucial molecule in the biological world, serving multiple roles beyond that of genetic material. While DNA is stable and well-known, RNA is less stable due to an extra oxygen atom, allowing it to function as a messenger that

Ethics, Peer-reviewed evidence, Reference Library, Resource Type

Understanding Levels of Evidence in Evidence-Based Medicine

Reference: Burns, P. B., Rohrich, R. J., & Chung, K. C. (2011). The levels of evidence and their role in evidence-based medicine. Plastic and Reconstructive Surgery, 128(1), 305–310. https://doi.org/10.1097/PRS.0b013e318219c171 Summary: This article discusses the importance of the hierarchical system of evidence levels in evidence-based medicine (EBM), particularly in plastic surgery. Originating from a 1979 report

Ethics, Other scientific evidence, Reference Library, Resource Type

Risk Communication in Healthcare

Reference: U.S. Department of Health and Human Services, Food and Drug Administration. (2011). Communicating risks and benefits: An evidence-based user’s guide. Retrieved from FDA website Summary: The guide emphasises the importance of effective risk communication in healthcare, highlighting that organisations must provide clear, evidence-based information regarding the risks and benefits of products and services. It

Antigenic vaccines, General Health, Immunology, Other viral illnesses, Peer-reviewed evidence, Reference Library, Resource Type, Vaccines, Viral illnesses

Immunologic Activity and Safety of Autologous HIV RNA–Electroporated Dendritic Cells in HIV-1 Infected Patients

Reference: Routy, J.-P., Boulassel, M.-R., Yassine-Diab, B., Nicolette, C., Healey, D., Jain, R., Landry, C., Yegorov, O., Tcherepanov, I., Monesmith, T., Finke, L., & Sékaly, R.-P. (2010). Immunologic activity and safety of autologous HIV RNA–electroporated dendritic cells in HIV-1 infected patients receiving antiretroviral therapy. Clinical Immunology, 134(2), 140. https://doi.org/10.1016/j.clim.2009.09.009 Summary: This pilot study assessed the

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