Reference:
Crump, A. (2017). Ivermectin: enigmatic multifaceted ‘wonder’ drug continues to surprise and exceed expectations. The Journal of Antibiotics, 70(6), 495-505. https://doi.org/10.1038/ja.2017.11
Summary:
Over the last decae, ivermectin has gained recognition for its significant contributions to global health. Discovered from a soil microbe in Japan, it was developed by Satoshi Ōmura and William Campbell, who received prestigious awards for this breakthrough. Since its commercialisation in 1981, ivermectin has been pivotal in treating neglected tropical diseases like Onchocerciasis and Lymphatic filariasis, with over 1.5 billion treatments administered globally. Its broad-spectrum efficacy extends beyond parasitic infections, showing promise as an antibacterial, antiviral, and even anti-cancer agent. Despite extensive research, the exact mechanisms of action remain partially understood, yet the lack of resistance in human parasites is notable. Current and future applications of ivermectin include treating myiasis, trichinosis, and potential roles in malaria and leishmaniasis control. Its unique properties and delivery methods indicate that ivermectin may continue to provide innovative solutions for various health challenges.