SAVIMS

March 2022

COVID-19, Ivermectin, Peer-reviewed evidence, Resource Type, Treatment, Viral illnesses

Efficacy of Ivermectin in Early Treatment of Covid-19: A Randomised Controlled

Reference: Reis, G., Silva, E. A. S. M., Silva, D. C. M., Thabane, L., Milagres, A. C., Ferreira, T. S., dos Santos, C. V. Q., Campos, V. H. S., Nogueira, A. M. R., de Almeida, A. P. F. G., Callegari, E. D., Neto, A. D. F., Savassi, L. C. M., Simplicio, M. I. C., Ribeiro, […]

COVID-19, Reference Library, SAVIMS Documents, SAVIMS Publications, Vaccines

COVID-19 Vaccines Medical Evidence re-Effectiveness

Summary The document critically examines the effectiveness and safety of COVID-19 vaccines, questioning their ability to prevent infection and transmission of the SARS-CoV-2 virus. It asserts that there is no reliable scientific evidence supporting the vaccines’ effectiveness in preventing infection or transmission. It cites numerous studies indicating the vaccines’ limited impact, and highlights flaws in

COVID-19, Covid-19 vaccines, Peer-reviewed evidence, Resource Type, Vaccine effectiveness, Vaccines, Viral illnesses

Effectiveness of Ad26.COV2.S Vaccine in South African Health-Care Workers

Reference: Bekker, L.-G., Garrett, N., Goga, A., Fairall, L., Reddy, T., Yende-Zuma, N., Kassanjee, R., Collie, S., Sanne, I., Boulle, A., Seocharan, I., Engelbrecht, I., Davies, M.-A., Champion, J., Chen, T., Bennett, S., Mametja, S., Semenya, M., Moultrie, H., de Oliveira, T., Lessells, R. J., Cohen, C., Jassat, W., Groome, M., Von Gottberg, A., Le

Ethics, Peer-reviewed evidence, Reference Library, Resource Type

The Illusion of Evidence-Based Medicine

Reference: Jureidini, J., & McHenry, L. B. (2022). The illusion of evidence-based medicine. BMJ, 376, o702. http://doi.org/10.1136/bmj.o702 Summary: The authors Jon Jureidini and Leemon B. McHenry argue that evidence-based medicine (EBM) has been compromised by corporate interests, inadequate regulation, and the commercialisation of academia. Although EBM was intended to provide a robust scientific foundation for

COVID-19, Epidemiological surveillance, Excess deaths, Other scientific evidence, Statistical evidence, Viral illnesses

Adverse Mortality Trends in the U.S Part II.

Reference: Author. (2022). Adverse mortality trends in U.S. using age stratified excess mortality. Retrieved from https://www.cdc.gov/nchs/nvss/vsrr/covid19/excess_deaths.htm#dashboard Summary: The article examines adverse mortality trends in the U.S. through age-stratified excess mortality analysis. It highlights a concerning shift whereby excess deaths among younger populations have significantly increased, while those among the elderly have declined, potentially due to

COVID-19, Covid-19 vaccines, Epidemiological surveillance, Peer-reviewed evidence, Resource Type, Statistical evidence, Vaccine effectiveness, Vaccines, Viral illnesses

Indirect Protection of Children from SARS-CoV-2 Infection through Parental Vaccination

Reference: Hayek, S., Shaham, G., Ben-Shlomo, Y., Kepten, E., Dagan, N., Nevo, D., Lipsitch, M., Reis, B. Y., Balicer, R. D., & Barda, N. (2022). Indirect protection of children from SARS-CoV-2 infection through parental vaccination. Science, 375(6585), 1155–1159. https://doi.org/10.1126/science.abm3087 Summary: The article investigates the indirect protection conferred to unvaccinated children against SARS-CoV-2 through parental vaccination

COVID-19, Covid-19 vaccines, Excess deaths, Other scientific evidence, Resource Type, Statistical evidence, Vaccine safety & adverse events, Vaccines, Viral illnesses

Adverse Mortality Trends in the U.S. Part I

Reference: Author. (2022). Adverse mortality trends in U.S. using age stratified excess mortality. Retrieved from https://www.cdc.gov/nchs/nvss/vsrr/covid19/excess_deaths.htm#dashboard Summary: The article examines persistent excess mortality trends in the U.S. since the onset of the COVID-19 pandemic. Despite advancements such as vaccinations, herd immunity, and the emergence of less severe virus variants, excess mortality rates have not declined.

COVID-19, Covid-19 vaccines, Epidemiological surveillance, Other scientific evidence, Resource Type, Statistical evidence, Vaccine effectiveness, Vaccines, Viral illnesses

Impact of Vaccination on SARS-CoV-2 Evolution

Reference: Vanden Bossche, G. (2022). Poor virus-neutralizing capacity in highly C-19 vaccinated populations could soon lead to a fulminant spread of SARS-CoV-2 super variants that are highly infectious and highly virulent in vaccinees while being fully resistant to all existing and future spike-based C-19 vaccines. Summary: In his article, Vanden Bossche (2022) raises concerns about

Ethics, Other scientific evidence, Reference Library, Resource Type

Understanding Levels of Evidence in Clinical Practice

Reference: Oxford Centre for Evidence-Based Medicine. (2009). Levels of evidence. Retrieved from https://www.cebm.ox.ac.uk/resources/levels-of-evidence/oxford-centre-for-evidence-based-medicine-levels-of-evidence-march-2009 Summary: The Oxford Centre for Evidence-Based Medicine’s Levels of Evidence document provides a structured approach to evaluating clinical evidence across various question types, such as therapy, diagnosis, and prognosis. It categorises evidence into levels, ranging from systematic reviews of randomised controlled trials

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