Reference:
Shimabukuro, T. T., Kim, S. Y., Myers, T. R., Moro, P. L., Oduyebo, T., Panagiotakopoulos, L., … & Meaney-Delman, D. M. (2021). Preliminary findings of mRNA Covid-19
vaccine safety in pregnant persons. New England Journal of Medicine, 384(24), 2273-2282. https://doi.org/10.1056/NEJMoa2104983
Summary:
The article evaluates the safety of mRNA Covid-19 vaccines in pregnant individuals, utilising data from the v-safe surveillance system, the v-safe pregnancy registry, and the Vaccine Adverse Event Reporting System (VAERS). Between December 14, 2020, and February 28, 2021, 35,691 pregnant participants reported local and systemic reactions to the vaccine. Results indicated that injection-site pain occurred more frequently among pregnant individuals than nonpregnant women, while other symptoms were reported less often. Among 827 completed pregnancies, the live birth rate was 86.1%, with 13.9% resulting in loss, aligning with historical data. No significant safety signals were identified, although a higher percentage of preterm births and small size for gestational age were noted. The findings highlight the necessity for continued monitoring to assess long-term maternal, pregnancy, and infant outcomes associated with vaccination.