Reference:
Shimabukuro, T. T., Kim, S. Y., Myers, T. R., Moro, P. L., Oduyebo, T., Panagiotakopoulos, L., Marquez, P. L., Olson, C. K., Liu, R., Chang, K. T., Ellington, S. R., Burkel, V. K., Smoots, A. N., Green, C. J., Licata, C., Zhang, B. C., Alimchandani, M., Mba-Jonas, A., Martin, S. W., Gee, J. M., & Meaney-Delman, D. M. (2021). Preliminary findings of mRNA Covid-19 vaccine safety in pregnant persons. New England Journal of Medicine, 384(24), 2273-2282. https://doi.org/10.1056/NEJMoa2104983
Summary:
This study assessed the safety of mRNA Covid-19 vaccines in pregnant individuals using data from the v-safe monitoring system and pregnancy registry. Of 35,691 participants, local reactions were similar to non-pregnant women, with increased reports of injection-site pain. Among 827 completed pregnancies, 86.1% resulted in live births, and 13.9% in losses. Adverse neonatal outcomes included 9.4% preterm births and 3.2% small size for gestational age. No significant safety concerns were identified, but further monitoring is
essential.