Reference:
Morens, D. M., Taubenberger, J. K., & Fauci, A. S. (2023). Rethinking next-generation vaccines for coronaviruses, influenza
viruses, and other respiratory viruses. Cell Host & Microbe, 31, 146-157. https://doi.org/10.1016/j.chom.2022.11.016
Summary:
The article discusses the challenges in developing effective vaccines for respiratory viruses such as SARS-CoV-2 and influenza. These viruses often replicate rapidly in the respiratory mucosa without inducing robust long-term immunity, complicating vaccination efforts. The authors highlight the need for next-generation vaccines that can elicit strong mucosal immune responses. They explore various factors affecting vaccine efficacy, including antigen configuration, administration routes, and public health considerations. The paper emphasizes the importance of understanding the immune system’s relationship with these viruses to create successful vaccines. It calls for innovative approaches and a rethinking of existing vaccination strategies to improve protection against respiratory viral infections.