Reference:
McCullough, P. A., Alexander, P. E., Armstrong, R., Arvinte, C., Bain, A. F., Bartlett, R. P., … & Zelenko, V. (2020). Multifaceted highly targeted sequential multidrug treatment of early ambulatory high-risk SARS-CoV-2 infection (COVID-19). Reviews in Cardiovascular Medicine, 21(4), 517–530. https://doi.org/10.31083/j.rcm.2020.04.264
Summary:
The article discusses a comprehensive approach to treat early ambulatory high-risk COVID-19 patients using Sequential Multidrug Therapy (SMDT). It highlights the urgent need for early intervention to prevent serious complications, hospitalisation, and mortality associated with SARS-CoV-2. The authors argue that a single-drug strategy is ineffective against the multifaceted pathophysiology of COVID-19, which includes viral replication, cytokine storms, and thrombosis. SMDT combines various therapeutic modalities, including nutraceuticals, anti-infectives, corticosteroids, and anticoagulants, aimed at addressing all aspects of the disease. The article reviews the state of global treatment strategies and advocates for the implementation of early home-based treatment regimens. It stresses the importance of telemedicine and the provision of medications to mitigate the severity of symptoms before hospitalisation becomes necessary. The authors conclude that SMDT, when tailored to individual risk profiles, has the potential to significantly reduce morbidity and mortality in high-risk COVID-19 patients and should be standard practice until effective vaccines achieve broad population immunity.