Reference:
Aldén, M., Olofsson Falla, F., Yang, D., Barghouth, M., Luan, C., Rasmussen, M., & De Marinis, Y. (2022). Intracellular reverse transcription of Pfizer BioNTech COVID-19 mRNA vaccine BNT162b2 in vitro in human liver cell line. Current Issues in Molecular Biology, 44, 1115–1126. https://doi.org/10.3390/cimb44030073
Summary:
This study investigates how the Pfizer BioNTech COVID-19 mRNA vaccine BNT162b2 interacts with the human liver cell line Huh7. Results show that BNT162b2 rapidly enters these cells and is reverse transcribed into DNA within 6 hours. The study highlights significant changes in the expression of LINE-1, an endogenous reverse transcriptase, after exposure to the vaccine. The findings raise concerns about potential genomic integration and the need for further research on the long-term effects of the vaccine on liver function and genomic integrity.