Reference:
Liu, J., Wang, J., Xu, J., Xia, H., Wang, Y., Zhang, C., Chen, W., Zhang, H., Liu, Q., Zhu, R., Shi, Y., Shen, Z., Xing, Z., Gao, W., Zhou, L., Shao, J., Shi, J., Yang, X., Deng, Y., Wu, L., Lin, Q., Zheng, C., Zhu, W., Wang, C., Sun, Y. E., & Liu, Z. (2021). Comprehensive investigations revealed consistent pathophysiological alterations after vaccination with COVID-19 vaccines. Cell Discovery, 7, 99. https://doi.org/10.1038/s41421-021-00329-3
Summary:
This article investigates the physiological changes in healthy individuals post-vaccination with an inactivated SARS-CoV-2 vaccine. Data revealed alterations in metabolic markers, such as hemoglobin A1c
and electrolyte levels, alongside immune responses mimicking those seen in COVID-19 patients. Single-cell RNA sequencing showed significant shifts in immune cell populations, including reduced CD8+ T cells and increased monocytes. The study highlights enhanced NF-κB signalling and diminished type I interferon responses, raising concerns about the immune system’s vulnerability post-vaccination. The authors recommend caution for individuals with pre-existing health conditions, suggesting that vaccination may induce a temporary state resembling infection rather than providing robust immunity.