Reference:
Kannemeier, C., Shibamiya, A., Nakazawa, F., Trusheim, H., Ruppert, C., Markart, P., Song, Y., Tzima, E., Kennerknecht, E., Niepmann, M., von Bruehl, M.-L., Sedding, D., Massberg, S., Günther, A., Engelmann, B., & Preissner, K. T. (2007). Extracellular RNA constitutes a natural procoagulant cofactor in blood coagulation. Proceedings of the National Academy of Sciences, 104(15), 6388-6393. https://doi.org/10.1073/pnas.0608647104
Summary:
The study investigates the role of extracellular RNA in blood coagulation, highlighting its function as a procoagulant cofactor. Upon vascular injury, RNA from damaged cells activates coagulation factors XII and XI, enhancing blood clotting. The research demonstrates that RNA promotes thrombus formation in vivo and shows potential as a target for antithrombotic therapies. RNase treatment was found to delay thrombus formation in experimental models, suggesting RNA’s significant role in coagulation processes during severe tissue damage. These findings reveal new insights into vascular repair mechanisms and potential therapeutic interventions.